DAPT
分类: 最上层  发布时间: 2018-03-20 18:36 

DAPT
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货号: INO1001-0005MG
保存条件: -20℃
CAS号: 208255-80-5
供应商: 上海伟进生物科技有限公司
数量: 10
英文名: DAPT
保质期: 2 years
规格: 5mg

Biological Activity

 

DAPT is a functional γ-secretase inhibitor and significantly reduces the production of total Aβ and Aβ42 in human primary neuronal cultures (IC50= 115 nM for total Aβ, IC50= 200 nM for Aβ42) [1], as well as in brain extract, CSF, and the plasma in vivo dose- and time-dependently [2]. DAPT efficiently blocks Notch signaling in hybrid human-mouse fetal thymus organ culture (FTOC) [3]. DAPT decreases lymphoproliferation in CBA-lpr mice and autoimmunity in MRL-lpr mice. By using a novel intermittent low-dose schedule, DAPT is well tolerated for months and the reported side effects of γ-secretase inhibitor are avoided [4]. DAPT-mediated suppression of Notch response enhances neuronal differentiation in ESCs-derived embryoid bodies (EBs) independently of SHH signaling [5].

 

Chemical Properties

 

Cas No.: 208255-80-5

M. Wt.: 432.46

Formula: C23H26F2N2O4

Purity: >98.5%

Synonym: GSI-IX, LY-374973

Chemical Name: N-[N-(3,5-difluorophenacetyl)-l-alanyl]-S-phenylglycine t-butyl ester

Appearance: White solid

Solubility: Soluble in DMSO (85 mg/mL) and in ethanol (50 mg/mL). Slightly soluble in water (<1 mg/ml).

Storage: Store solid at -20 ºC for the stability of two years

温馨提示:不可用于临床治疗。
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