Purmorphamine
分类: 最上层  发布时间: 2018-03-20 18:36 

Purmorphamine
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货号: ISH1021-0001MG
保存条件: -20℃
CAS号: 483367-10-8
供应商: 上海伟进生物科技有限公司
数量: 10
英文名: Purmorphamine
保质期: 2 years
规格: 1mg

Biological Activity

 

Purmorphamine is a 2,6,9-trisubstituted purine compound that selectively induces osteogenesis in multipotent mesenchymal progenitor cells. The small molecule Purmorphamine has been found to activate Hedgehog (Hh) signaling pathway by directly targeting Smoothened (Smo), resulting in the up- and down-regulation of its downstream target genes, including Gli1 and Patched. The EC50 of purmorphamine for differentiation of C3H10T1/2 cells based on alkaline phosphatase (ALP) expression is 1 µM. This compound may ultimately be useful for the treatment of bone-related disease and neurodegenerative disease [1-3]. Purmorphamine can replace sonic hedgehog (SHH) in the entire process of ventral spinal progenitor specification and motor neuron differentiation with a similar efficiency [4].

 

Chemical Properties

 

Cas No.: 483367-10-8

M. Wt.: 520.62

Formula: C31H32N6O2

Purity: >98%

Chemical Name: 9-cyclohexyl-N-(4-morpholin-4-ylphenyl)-2-naphthalen-1-yloxypurin-6-amine

Appearance: White to off-white solid

Solubility: Soluble in DMSO up to 50 mM

Storage: Store powder at +4 ºC desiccated. Following reconstitution, aliquot and freeze at -20 ºC, prevent from repeated freeze/thaw cycles.

温馨提示:不可用于临床治疗。
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