PI-103 (P110α/DNA-PK/mTOR inhibitor)
分类: 最上层  发布时间: 2018-03-20 19:19 

PI-103 (P110α/DNA-PK/mTOR inhibitor)
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货号: IPA1004-0005MG
保存条件: -20℃
CAS号: 371935-74-9 
供应商: 上海伟进生物科技有限公司
数量: 10
英文名: PI-103
保质期: 2 years
规格: 5mg

Biological Activity

PI-103 is a potent, cell-permeable, ATP-competitive PI3K family members inhibitor with IC50 of 2, 8, 20, 26, 48, 83, 88, 150 nM for DNA-PK, p110α, mTORC1, PI3-KC2β, p110δ, mTORC2, p110β and p110γ, respectively. It shows little activity against a wide array of protein kinases at 10 mM [1]. PI-103 exhibits antiproliferative activity against a panel of glioma cell lines in vitro at a concentration of 0.5 µM. It also inhibits growth of established human glioma tumor xenografts in vivo with no observable toxicity [2].In blast cells, PI-103 suppresses leukemic proliferation, the clonogenicity of leukemic progenitors and induced mitochondrial apoptosis, especially in the compartment containing leukemic stem cells [3].

 

Chemical Properties

Cas No.: 371935-74-9

M. Wt.: 348.36

Formula: C19H16N4O3

Purity: >99%

Synonym: PI 103

Chemical Name: 3-(4-(4-Morpholinyl)pyrido[3’,2’:4,5]furo[3,2-d]pyrimidin-2-yl)phenol

Appearance: Off white to white solid

Solubility: Soluble in DMSO at 10 mg/ml, slightly soluble in water.

StorageStore powder at -20 ºC for the stability up to two years, keep desiccated.

温馨提示:不可用于临床治疗。
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